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Pfizer Drug Delays Progression of Breast Cancer

April 8, 2014 By Roxanne Briean Leave a Comment

A clinical drug trial conducted with the palbociclib manufactured by Pfizer showed the medication was able to delay the progression of breast cancer by almost two years.

The trial was part of a study of Phase 2 on 165 women who had breast cancer. Researchers were able to find that women treated with the drug as well as letrozole a hormone drug lived for 20.2 months prior to the cancer becoming worse. Those results were compared to just over 10 months for those patients who received only letrozole hormone drug.

Pfizer said that palbociclib was one of the pharmaceutical giant’s most important medications. Some industry analysts claim that once this drug has been received regulatory approval, it most likely will have sales in excess of $5 billion annually.

The medication is to be used for women who are post-menopausal with newly diagnosed or locally advance breast cancer, which has spread into other areas of their body.

All the women that participated in the trial had estrogen receptor and HER2-negative cancer.

Recent statistics show 60% of the cases of breast cancer that is advanced are HER2-negative and estrogen receptor positive.

Letrozole is a drug than is an estrogen blocker which Novartis AG sells under the name Femara. Women treated with Femara alone have a 33.3 month overall survival rate.

Scientists found that when Letrozole is given together with palbociclib, the survival rate overall increased by over 37 months.

The U.S. Food and Drug Administration granted palbociclib breakthrough status. It is not certain if manufacturers of the drug will decide to seek an accelerated approval due to the trial results.

However, researchers have said that even though just 30 patients that were in each section of the trial of 165 patients had died, more time was needed to make a definition of the impact on the survival rate the drug has.

Today, the second deadliest cancer amongst women in the United States is breast cancer. The cancer affects more than 200,000 annually, killing nearly 40,000 each year.

Experts estimate that one in every eight females will at some time in their lives develop breast cancer.

While there is no known cause risk factors do include late menopause, early puberty and certain types of genes.

Filed Under: Business, Headlines

Indian Court Hands Out Death Sentences

April 4, 2014 By Roxanne Briean Leave a Comment

A court in the financial hub of India sentenced three men, who had been found guilty of gang rapes, to death.

The sentences of death were the first handed down following the government’s increased penalties for sex crimes after the gang rape that killed a young female bus passenger in New Delhi back in December of 2012.

The three men, who were given the death sentences on Friday in Mumbai in western India, had been convicted of the gang rape of a photojournalist in a sawmill compound that had been abandoned. The three were also found guilty of raping another female in the same location in an attack that was unrelated.

In addition, on Friday another court in the southern region of India overturned 24 men’s acquittals that had been involved in a case of a teenager who had been raped for a number of weeks 18 years ago in southern India.

The Kerala High Court handed down a sentence of life to one man and the other 23 were given prison terms of varying years, that ranged from 7 to 11 years.

The girl who had been raped over 18 years ago was raped at least once by more than 40 men in different places over a period of 40 days in Tamil Nadu and Kerala. Officials in the court said the woman’s rapists included lawyers, professor, government officials and businessmen.

While the gang rape for multiple days took place in 1996, the men were given acquittals back in 2005. However, the top court in India ordered that a retrial be held last year.

The justice system in India moves at a snail’s pace, but the gang rape in December of 2012 unleashed public outcry and anger across the country over how women are treated and the long epidemic that most often went unspoken of sexual violence.

A strict law against rape and trials that take place faster were amongst the changes that took place in the India legal system.

The woman killed in December of 2012 had been picked up by a bus along with her companion when five men on the bus, who had been drinking while driving around New Delhi, beat her companion and raped and beat her before throwing both from the bus.

Filed Under: Headlines

Strong Earthquake Hits Northern Chile

April 2, 2014 By Roxanne Briean Leave a Comment

A powerful earthquake with an epicenter off the northern coast of Chile was registered with a magnitude of 8.2, which lead to six deaths. The quake prompted officials from Chile to evacuate the northern coast of the country due to fears of a tsunami.

The warning of a tsunami was issued for all of the South America coastline on the Pacific Coast though it was later lowered to a threat of a tsunami and eventually lifted entirely.

Rodrigo Penailillo the interior minister said six people were killed attributing the deaths to people being crushed and suffering heart attacks.

President Michelle Bachelet said early Wednesday that she had declared a state of catastrophe in the nation’s northern section in the regions of Tarapaca, Parinacota and Arica.

The military was traveling to those areas in order to avoid looting.

A wave of approximately six feet came ashore in Iquique a port city according to a deputy interior minister. The city was located 59 miles from the epicenter of the quake.

Chile sent armed forces to the city as well after more than 300 prison inmates were able to flee a prison for women during the chaos that followed the quake.

In the small town of Huara, located between Arica and Iquique, Mayor Carlos Silva said people in that area were prepared for an earthquake since there had been many small shakes. He said they had utilized a very efficient plan for evacuation.

Images on Chilean television were of people walking quickly to evacuate Antofagasta a coastal city. Viewers were advised by newscasters to buy candles and use social media in a responsible way as well as not to use any elevators when evacuating.

Officials were also evacuating people living on Easter Island off the coast, said the National Police of Chile.

Callers into a program on the radio said the earthquake had lasted a long time and had been very strong, causing great chaos in city streets with large sections losing electricity. Some roads in the area had been damaged, said the radio station.

The mayor of Arica in the north said he did not have reports of damage, although he was aware of some homes damaged by the shaking.

This quake followed hundreds of smaller temblors that hit the same area the past couple of weeks, which increased the fears a larger one would hit.

Filed Under: Headlines

Study: Statins Help Erectile Dysfunction

April 1, 2014 By Roxanne Briean Leave a Comment

Statins, the cholesterol lowering medications that are hugely popular might help males who suffer from erectile dysfunction. At the Robert Wood Johnson Medical School at Rutgers, scientists led a first ever meta-analysis of studies done previously over the link between statins and erectile dysfunction.

The team, with Dr. John Kostis in the lead, analyzed 11 previous trials in order to find an effect that was significant of statins on ED in males who had both erectile dysfunction and high cholesterol. The results, said researchers showed the scores for erectile dysfunction increased.

It already is known that statins might work in a similar what to Viagra by helping the blood vessels to dilate properly which improves vascular blood flow into the penis, which in males with ED is restricted.

Dr. Kostis said that increase in the scores for ED with statins was about a third to, as much as one-half of what was reported with Viagra, Levitra and Cialis.

The doctor added that the effect of the statins was greater than that of lifestyle medication or testosterone.

Doctors and researchers said that statins were not a recommended primary treatment for males with erectile dysfunction in males that have healthy levels of cholesterol.

ED affects between 18 million and 30 million males across the globe. It occurs more frequently in males age 40 and above. Common causes of ED included high cholesterol, heart disease, diabetes, high blood pressure, obesity, depression, stress and tobacco use.

A study on ED carried out by the University of Adelaide shows that effects of ED could be reversed through changes in lifestyle.

Lowering alcohol consumption, increasing daily physical activity, sleeping for longer periods and eating healthier were factors that helped erectile function in the study that included 810 men.

The led author of that study, Professor Gary Wittert said the biggest risk factors for ED typically were for physical conditions rather than ones that were psychological.

The results from the study showed that a large proportion of males were overcoming issues of erectile dysfunction naturally, with a remission level of as high as 29%, showing many of the things that cause ED are modifiable.

Filed Under: Headlines, Life

Study: Erectile Dysfunction Reversible

March 29, 2014 By Roxanne Briean Leave a Comment

Erectile dysfunction can strike even men who are still young. In the U.S., the 45th top selling prescription is Viagra. Men who have ED should be told that if they require a prescription due to not obtaining or maintaining an erection there might be other problems with their health that should be addressed.

The results from a new study have shown the ED could be reversed without the use of a pill. The study shows that lifestyle changes can be made so there is an improvement in sexual function to reverse ED.

ED is not something men should just ignore, as sexual dysfunction can be caused by any number of different health ailments, that could possibly be debilitating and in certain instances even fatal.

Health problems leading to erection problems can include sleep apnea, obesity, overweight and poor sleep. In addition, high intake of alcohol could interfere with a man having the ability of obtaining an erection. Aging has also been associated with ED.

A male can address certain things to improve his sexual function without the use of medications. Those issues included but are not limited to improving sleep, exercising more, reducing alcohol consumption, healthy diet, weight loss if needed, lowering cholesterol, controlling diabetes and lowering the blood pressure.

In simple terms, researchers said that having a healthy lifestyle could reverse ED in some men.

Medications are another reason men can suffer from ED. Smoking is a risk factor due to constricting the blood vessels reducing the overall flow of blood.

In the study, researchers studied men from Australia that had ED problems between the ages of 35 and 80.

The study found that 29% of men were able to reverse their problems due to ED by changes in lifestyle, which is a significant number and shows options exist other than just taking prescription medications for ED.

In the investigation, many of the men developed ED that researchers said was a concern.

Filed Under: Headlines, Life

easyJet Lifts Forecast for First Half

March 25, 2014 By Roxanne Briean Leave a Comment

easyJet the budget airline based in Britain upgraded its forecast for the first half by 25% Tuesday, which sent its shares near an all-time high. This followed tight cost cutting measures and huge popularity of is seating program.

easyJet said it was expecting a loss pretax of between $91 million and $107 million, which was an improvement of a previous forecast of a loss of between $115 million and $147 million.

The airline, which, as its rivals does, traditionally has losses during the winter as fewer people fly. The airline reported a $100 million loss in 2012-13 for the same period.

The upgrade to the forecast was helped due to benign weather that meant there were fewer disruptions that were weather related, said the airline.

easyJet has in the past 12 months taken more share from rival Ryanair through the introduction of measures like allocated seating as well as allowing passengers the chance to change flights to better appeal to the business traveler.

Shares of easyJet have increased by over 60% during the past 12 months. In early premarket trading, the shares were up 4.4% putting them close to their all-time high that was reached in early March of this year.

Airline analysts said although the airline did not comment on its fiscal second half, an upgrade was likely to be the consensus for their forecasts.

Carolyn McCall the CEO at easyJet said the airline’s upgrade show the company’s structural advantage it held not just against other low cost airlines like Ryanair, but the other legacy carriers.

The former entities that were state-owned like Lufthansa in Germany are fighting against the carriers that are low-cost to keep market share across Europe in the sector of short-haul

Revenue per each seat during the six-month frame should rise by 1.5% said easyJet, which was higher than a January forecast thanks to a boost received from the allocated seating program and other airline initiatives.

The improvement forecast by easyJet for the first half comes even though it was hit by additional fuel costs compared to the same time during 2012-13.

Filed Under: Business, Headlines

Motel Fire in New Jersey Claims Three Lives

March 21, 2014 By Roxanne Briean Leave a Comment

Three people were pronounced dead by authorities following an early morning fire on Friday that destroyed a motel that was two-story tall, said police.

Officials are continuing to search room by room at the Mariner’s Cove Motor Inn. Sources said it was too hard to tell if the amount of fatalities from the fire would increase.

A number of other people suffered injuries due to the blaze, as many had to leap from the motel’s second floor, said police. Other suffered smoke inhalation and burns.

An officer from the Sheriff’s office in Ocean County was injured, but police do not know how severe his injuries are.

Firefighters from three towns – South Wall, Point Pleasant Beach and Point Pleasant – were called in to battle the fire that had been first reported between 4:30 a.m. and 4:45 a.m.

As late as 8:00 a.m. Friday morning there were still more than 50 firefighters on the scene.

The motel did not have concrete walls said one resident of Point Pleasant and therefore it became engulfed very quickly.

One woman at the scene, who did not want to leave her name, told reporters she was hoping to hear news about a friend who lived at the motel.

The manager’s office had been destroyed in the fire and no records have been obtained about residents in the motel.

Dogs able to detect accelerants and cadavers were being brought to the motel early Friday morning. Victims were taken to a squad building for first aid, and the American Red Cross was called to assist.

Authorities said they would hold a news conference before noon. The fire will be investigated jointly by the sheriff’s offices and the county prosecutor. In addition, the Point Pleasant police and the fire marshal from the country will also take part.

Properties that were adjacent to the motel received damage. The motel is open all year. It has been opened since 1985.

The motel, which is L-shaped, is just blocks for the beach, boardwalk and Manasquan Inlet.

Filed Under: Headlines

Parliament in Crimea Formally Applies to Be Part of Russia

March 17, 2014 By Roxanne Briean Leave a Comment

Parliament in Crimea has declared its independence formally from Ukraine and has asked to become a part of the Russian Federation.

This follows the controversial referendum from Sunday in which officials said overwhelmingly backed the succession from Ukraine.

The central government in Kiev said it would not recognize Sunday’s results. The EU and U.S. said the vote was not legal and vowed to impose numerous sanctions on Moscow.

The Crimean peninsula since the latter part of February has been under control of forces that are pro-Russia.

The EU will, going forward, have a review of whether it is dependent too much on energy from Russia.

This week the EU challenge is to show unity and resolve. Any obvious divisions would be exploited by Russia. The EU resolve would be delivering on the sanctions that have been warned about.

This crisis has come on the heels of the ousting of President Viktor Yanukovych who was pro-Moscow.

His decision rejecting the trade deal that had been long-awaited with the EU in favor of better and closer relations with Moscow, sparked street protests for months, which culminated in clashes that were deadly.

Arseniy Yatsenyuk the interim Prime Minister of Ukraine called the vote on Sunday a circus performance supported by Russian troops that reached 21,000, who with guns are attempting to prove the referendum’s legality.

The vote had been boycotted by many amongst the minority in Crimea, the Tatars and Ukrainians who are only about one third of the peninsula’s population.

At the same time, the government in Kiev formally approved the mobilization of 40,000 reservists.

The National Security and Defense Council Secretary Andriy Parubiy said that the incidents in Crimea were blatant aggression and that mobilization would prevent action of a similar kind in the southeastern part of Ukraine, which has had rallies that were pro-Moscow lately.

On Monday, according to the Crimea parliament vote, the laws of Ukraine no longer are applicable in the region and that all state property of Ukraine is now part of the independent Crimea.

Filed Under: Headlines

U.S. Government Loosens Grip on Internet

March 15, 2014 By Roxanne Briean Leave a Comment

After first incubating it and then overseeing it for a number of decades, the government of the U.S. announced on Friday to would release the final elements of control it had on the Internet.

The U.S. Commerce Department originally handled the core parts of Internet, but has gradually pulled back from those important duties, through a contract that is in place with a nonprofit organization named Internet Corporation for Assigned Numbers and Names or ICANN.

On Friday, in a prepared statement, the Commerce Department requested ICANN to convene the parties involved to formalize an approach that is multistakeholder for governance of the Internet.

The basics of that work is involved in running the DNS or Domain Name System of the Internet, which translates Internet Protocol numeric addresses into the more human readable convenient domain names such as xyz.com. In addition, manage the root servers holding those records of DNS for use by other machines. As well as, to oversee the ongoing explosive growth of the new top-level domain names like .cleaning, .social and .berlin.

This has been a wait of a long time, as the process of privatization started in 1997 under then-President Bill Clinton. In an interview two months ago, Fadi Chehade, the CEO of ICANN said the oversight by the U.S. is no longer sustainable.

ICANN has grown and matured, the Department of Commerce committed to handing over the responsibility at a certain point and the recent revelations over the government’s surveillance from the Edward Snowden leaks increased the necessity to hand over control now, said Chehade.

Chehade added that the revelations by Snowden hastened the dialog for a hand over. Many companies that do business internationally were worried due to a lack of a trust factor over the Internet.

Working closer to the hand over, ICANN already set up a meeting on the governance of the Internet for April 23-24 in Brazil. The DOC generally is together with ICANN on using the term multistakeholder.

The stakeholders included the Internet Architecture Board, the Internet Engineering Task Force, the Regional Internet Registries and the Internet Society.

The Registries oversees the IP address distribution to those that register new domain names.

Filed Under: Headlines, Tech & Science

Driver Plows into Group at Austin Festival Killing Two

March 13, 2014 By Roxanne Briean Leave a Comment

In the early morning hours of Thursday, two people were killed while two dozen were injured when a driver that was being pursued by the police plowed into a crowd of people that were celebrating in Austin, Texas as the South By Southwest festival.

A police officer from Austin said the suspect drove through a number of temporary barricades that had been set up specifically for the event at Red River and 9th streets. The suspect was fleeing after police attempted to stop the car for a traffic stop.

At that time, the driver fled driving the wrong way on 9th, which is a one-way street, running into the crowd, striking a number of pedestrians and colliding with a taxi and moped. When the suspect’s car stopped, he tried to flee but was tased and put into police custody.

The two people killed were confirmed dead by rescue personnel at the scene. Those injured were transported to nearby hospitals. The incident took place about 12:30 am local time.

One witness said she was at the festival when a car could be seen breaking the barricade and plowing through a number of people attending the festival.

She said people could be seen flying off the hood of the moving car. Blood was everywhere said another witness near people who were lying injured on the ground.

Another witness said he was leaving work just down from the accident minutes after it happened. He raced to the scene and found rescue personnel helping victims as sirens on police cars screeched and a helicopter kept vigil from above.

Many people could be seen crying while they looked over the many people injured. One witness said the festival is for celebration, but in an instance all that changed when the man’s car could be heard and then seen running into and over festivalgoers.

The police officer, who had been pursuing the suspect’s car prior to the tragedy, said he thought the driver might have been intoxicated.

Filed Under: Headlines, Life

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