Genentech’s bevacizumab, known as Avastin on the market, has procured validation use in combination chemotherapy for late-stage cervical cancer. The U.S. Food and Drug Administration shows “thumps up” to the approval and permits the medication of repetitive, endless metastatic cervical cancer with Avastin in conjointment with other chemotherapy drugs paclitaxel and cisplatin or in conjunction with topotecan.and paclitaxel.
“After the approval of cisplatin and topotecan in 2006, Avastin is the first drug validated for the last-stage cervical cancer patients”, said Richard Pazdur , M.D ., of the FDA’s Center for drug Evaluation and Research. Due to the potency and safety exhibited by Avastin over other band of therapies, the FDA rewarded the drug with an accelerated review process, and validates it under the priority review process.
The task of Avastin is to lowers a tumor’s ability to develop by targeting its formation and maintenance of blood vessels, a process known as angiogenesis and hence it is called angiogenesis inhibitor.
Genentech carried on several clinical trials on the preceding submission for review. The company carried on some studies involving up to 450 patients with repetitive, persistent and late-stage cervical cancer. The studies saw a steady progress in overall survival to 16.8 months with treatment of Avastin combined with chemotherapy, as compared to 12.9 months with chemotherapy alone.
Some side effects include fatigue, headaches, elevated blood pressure, appetite loss and weight loss. The company recommends women who are pregnant or are supposed to get pregnant to have a detailed conversation with their healthcare practitioners about the risks associated with the fetus in the usage of Avastin.
“The approval proved beneficial to the women with advanced cervical cancer who can now go for Avastin plus chemotherapy to help them live longer than with chemotherapy alone,” said Genentech’s chief medical officer Sandra Horning, M.D.
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