A new Mesoblast stem cell therapy is proved to work against rheumatoid arthritis
A new Mesoblast stem cell therapy is proved to work against rheumatoid arthritis.
The word arthritis means joint inflammation but is used to describe around 200 rheumatic diseases and conditions that affect joints and other connective tissue. Rheumatic conditions are typically characterized by pain, aching, stiffness and swelling in and around one or more joints.
Certain rheumatic conditions can also involve the immune system and various internal organs of the body. Some forms of arthritis, such as rheumatoid arthritis and lupus, can affect multiple organs and cause widespread symptoms.
According to data from a mid-stage trial, Mesoblast Ltd stated that its experimental stem cell approach towards patients with rheumatoid arthritis had improved the symptoms of the disease. This new stem cell therapy has been tried on patients whose arthritis couldn’t be held under control by widely used biotech medicines.
During its 12 week phase, the trial was conducted on 48 patients with active rheumatoid arthritis who were given an infusion of stem cell treatment promoted by the Australian biotech company.
To conclude that the treatment was efficient it had to carry through a 20 percent relief of signs and symptoms among patients. This measure is called ACR20.
Among patients treated with the stem cell infusion, 55 percent of them achieved ACR20. The treatment received by the patients contained 2 million cells per kilogram of body weight. Moreover, 33 percent of the patients in the placebo group also achieved the ACR20.
70 percent improvement, also called ACR70, was achieved by 36 percent of patients after the stem cell infusion, compared with no patients in the group given a placebo treatment.
Overall, physical functions and disease activity were improved during the cell treatment. The innovative treatment can fill the significant unmet medical need for patients that are unable to follow the biologic therapies. This much-needed remedy comes at a time when one-third of patients either cannot tolerate the biologic treatment or do not respond sufficiently.
Its safety and efficacy results are encouraging, but in order to compete with the general remedies, new therapies must approach both pain and disease progression.
The stem cell treatment has also been proved to work on chronic heart failure, inflammatory bowel diseases, cancers and bone marrow transplants.
Image source:Pixabay
Roxanne Briean
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